Новые достижения в лечении тонкого эндометрия

Abstract

Abstract_______________________________________________________________________

Introduction. Thin endometrium (<7 mm) is associated with a low probability of implantation in assisted reproductive technology (ART) programs. Effective methods for increasing the thickness of the endometrium remain the subject of active research.

Materials and methods. A retrospective study was conducted, including 156 patients with thin endometrium. Patients were divided into three groups: standard hormonal therapy, hormonal therapy with intrauterine administration of PRP (platelet-rich plasma), hormonal therapy using G-CSF. Changes in endometrial thickness, clinical pregnancy rate and implantation were assessed. Statistical analysis was performed using the t-test criterion at a significance level of p<0.05.

Results. In the hormonal therapy group, the endometrial thickness increased from 5.4±0.3 mm to 6.2±0.5 mm. With the use of PRP - from 5.2±0.4 mm to 7.1±0.6 mm (p<0.01), with G-CSF - from 5.3±0.5 mm to 6.9±0.7 mm (p<0.01). The clinical pregnancy rate was 23.5% in the first group, 42.9% in the second and 39.7% in the third (p<0.05 between the first and other groups).

Conclusions. Intrauterine administration of PRP or G-CSF against the background of hormonal therapy significantly increases the endometrial thickness and increases the likelihood of clinical pregnancy in patients with a thin endometrium. Biological methods can be recommended to expand treatment options in reproductive medicine.