ВЛИЯНИЕ ПОЛИМОРФИЗМА G20210A ГЕНА FII НА ЧАСТОТУ ТРОМБОЭМБОЛИЧЕСКИХ ОСЛОЖНЕНИЙ В ПОСТТРАВМАТИЧЕСКОМ ПЕРИОДЕ У ПАЦИЕНТОВ С ТЯЖЕЛЫМИ ПОВРЕЖДЕНИЯМИ НИЖНИХ КОНЕЧНОСТЕЙ

Abstract

The problem of high mortality in polytrauma remains relevant, showing indicators of 15-24% even in specialized medical institutions. Improving the organization of assistance and anti-shock therapy has led to a decrease in mortality in the early period after polytrauma, however, this is accompanied by an increase in the relative proportion of fatal outcomes associated with late complications. The development of venous thromboses in patients with polytrauma, as one of the late complications, is due to a complex of factors, including direct vascular damage, prolonged immobilization, pronounced disorders in the hemostasis system, and surgical operations. Along with the main factors, scientists also consider genetic factors that lead to the deterioration of the body's hypercoagulation background. One such unfavorable mutation is the polymorphism of blood plasma factor FII (G20210A).