НАТИВНЫЙ СТАФИЛОКОККОВЫЙ АНАТОКСИН

Abstract

А study was made of the staphylococcus antileukocidin production in the sera оf horses after hyperimmunization with crude staphylococcus toxoid prepared from the industrial staphylococcus strain O-15. A study was also made of the conditions of staphylococcus antileukocidin formation in the rabbit sera following immunization with the crude and purified sorbed staphylococcus toxoid. A mixture prepared from 5 crude leukocidins (4 strains of plasmocoagulating phylococcus aureus and 1 strain of Staphylococcus albus O-15) was used for antileukocidin titration. All the antisptaphylococcus horse sera (crude fluid and lyuophilized, as well as purified concentrated with the aid of Diapherm-3 method) contained antileukocidin; it was absent in control sera. In rabbits antileukocidin appeared in the blood sera only after revaccination with crude staphylococcus toxoid. In the same conditions nо antileukocidin was revealed in rabbits immunized and revaccinated with purified sorbed staphylococcus toxoid, although rabbits did acquire immunity to intradermal administration of staphylococcus culture and toxin.