ЗНАЧЕНИЕ ЦИРКУЛЯЦИИ ЖЕЛЧНЫХ КИСЛОТ И МИКРОБИОЦЕНОЗА КИШЕЧНИКА ПРИ НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ

Abstract

Background. Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and is considered a hepatic manifestation of metabolic syndrome. Disturbances in enterohepatic bile acid circulation and intestinal microbiota play a significant role in NAFLD pathogenesis.

Objective. To evaluate the effect of the lignin-based enterosorbent Zerotox on bile acid enterohepatic recirculation and intestinal microbiocenosis in patients with NAFLD.

Materials and Methods. The study included 56 patients with NAFLD divided into two groups: one receiving standard therapy with ursodeoxycholic acid, and the other receiving standard therapy combined with Zerotox. Fecal bile acid excretion and the degree of intestinal dysbiosis were assessed using standard laboratory and microbiological methods.

Results. Patients with NAFLD demonstrated increased fecal bile acid excretion, mainly due to primary cholic acid, along with significant intestinal microbiota disturbances characterized by a deficiency of bifidobacteria and lactobacilli. The addition of Zerotox led to normalization of bile acid profiles, reduced bile acid loss, and improvement of intestinal microbiocenosis.

Conclusion. Disorders of bile acid enterohepatic circulation and intestinal microbiota are key factors in NAFLD development. The inclusion of a lignin-based enterosorbent in complex therapy improves metabolic balance and enhances treatment outcomes.